Through pancreatic cell transplantation In a new study, a team of scientists has demonstrated the successful application of a new treatment for type 1 diabetes in an animal model. Their approach is to transplant insulin-producing pancreatic cells without the need for long-term use of immunosuppressive drugs. Discuss a method for treating diabetes” alt=”Scientists have developed a new method for treating diabetes” Scientists have developed a new method for treating diabetes />
According to Hawal Shirvan, professor of child health and molecular microbiology and immunology at the California State University School of Medicine, in people with type 1 diabetes, the immune system can malfunction, causing “self-attacks.”
Doctors have targeted a mechanism called apoptosis, which destroys rogue immune cells that cause diabetes or rejection of transplanted pancreatic islets, by attaching a molecule called FasL to the surface of the islets.
“A type of apoptosis occurs when a molecule called FasL interacts with another molecule called Fas on rogue immune cells and this causes them to die,” said one of the study's authors. “Therefore, our team pioneered the technology to produce a new form of FasL and present it on transplanted pancreatic islet cells or microgels to prevent rejection of rogue cells. After transplantation of insulin-producing pancreatic islet cells, rogue cells are mobilized to the graft for destruction, but are destroyed by FasL binding Fas on their surface.
One of the advantages of the new method is the possibility Potentially avoid lifelong immunosuppressive drugs that interfere with the immune system's ability to seek out and destroy a foreign object when it is introduced into the body, such as an organ transplant or, in this case, cells.
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